This collection of papers, articles, and commentaries provides insights into PCORI-funded work to advance patient-centered comparative clinical effectiveness research. PCORI is committed to the principles of transparency and openness in all of our work. We encourage authors to make their publications available without a subscription.
PCORI in the Literature
Comparative Effectiveness of Different Approaches to Weight Loss Management Programs
This PCORI-funded study compared three types of weight loss management programs for people with high blood pressure or type 2 diabetes who also had overweight or obesity. The study, led by Heather J. Baer, ScD, at Brigham and Women’s Hospital, compared outcomes of patients in three groups: an online weight management program with meal plans, menus, and a weight tracker; that same program plus support from a health manager; and usual care. As reported in JAMA, the group that used the online weight management program and had access to a health manager, on average, experienced a statistically significant greater weight loss after 12 months compared to the other two groups.
Antibiotics Treat Appendicitis As Well As Surgery for Most Patients in the Short Term
At least in the short term, using antibiotics to treat appendicitis worked as well as surgical removal of the appendix for most patients in the PCORI-funded CODA trial, as reported in the New England Journal of Medicine. Health outcomes associated with each treatment were similar. More than 70 percent of patients on antibiotics avoided having surgery and missed less time away from work or school in the three months post-treatment. However, nearly 30 percent who received antibiotics ultimately needed surgery. CODA was conducted at 25 sites nationwide and involved a wider range of patients than previous studies, making its results more broadly applicable to typical patients with appendicitis.